Journal
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
Volume 20, Issue 8, Pages 5014-5018Publisher
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jnn.2020.17844
Keywords
Carboxymethyl Chitosan; Waterborne Polyurethane; Tissue Engineering; Scaffolds
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Funding
- Basic Science Research Program of the National Research Foundation of Korea (NRF) [2017R1DIA31303031234]
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Bone tissue engineering has been rapidly developed in regenerative medicine field, which aims to induce new functional bone regeneration through the synergistic combination of biomaterials and cells. Porous biomaterials with sufficient mechanical properties and functional impregnating for bone substitutes have been imposed in the oncoming generation of bone reconstruction. In this study, we fabricated Carboxymethyl chitosan three dimensional (3D) porous scaffold modified with waterborne polyurethane (WPU) through freeze drying technique. In order to check its potential in bone tissue substitutes, osteoblast cells (hFOB 1.19) were seeded onto the fabricated scaffolds and then, SEM and proliferation assay were performed. The enhanced proliferation was contributed to 3D macroporous network structure, large surface area, and osteoconductive environments.
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