Journal
JOURNAL OF MOLECULAR MEDICINE-JMM
Volume 98, Issue 9, Pages 1215-1234Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00109-020-01953-4
Keywords
Gene targeting; Genetics; Inbred; Mouse; Phenotype; Transgenic
Funding
- Hong Kong Polytechnic University [ZVN0]
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The laboratory mouse is the most commonly used mammalian model for biomedical research. An enormous number of mouse models, such as gene knockout, knockin, and overexpression transgenic mice, have been created over the years. A common practice to maintain a genetically modified mouse line is backcrossing with standard inbred mice over several generations. However, the choice of inbred mouse for backcrossing is critical to phenotypic characterization because phenotypic variabilities are often observed between mice with different genetic backgrounds. In this review, the major features of commonly used inbred mouse lines are discussed. The aim is to provide information for appropriate selection of inbred mouse lines for genetic and behavioral studies.
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