Equilibrium solubility and modeling of trans-resveratrol in dichloromethane and primary alcohol solvent mixtures at different temperatures

The solubility of trans-resveratrol in a solvent of primary alcohols (methanol, ethanol, n-propanol, n-butanol) + dichloromethane prepared at various mass fractions was measured at different temperatures (283.15-303.15 K) under atmospheric pressure. The solubility profile of turns-resveratrol in the solvent mixture was markedly dependent on temperature and solvent composition. The solubility increased as temperature and the mass fraction of the primary alcohol increased. The maximum solubility in each solvent mixture was in the following order: ethanol > methanol > n-propanol > n-butanol. The mass fraction of the primary alcohol reached the highest solubility at 1.0, and the slope gradually decreased as the mass fraction increased. Several computational models, such as van't Hoff, modified Apelblat, simplified CNIBS/R-K, Jouyban-Acree, Jouyban-Acree-van't Hoff, Jouyban-Agee-modified Apelblat, Ma, and Sun models were employed to analyze the experimental solubility data. The dissolution of trans-resveratrol in the primary alcohol - dichloromethane mixture was confirmed to be endothermic and spontaneous according to the obtained thermodynamic parameters. The solubility data for the primary alcohol + dichloromethane binary mixtures obtained herein could be used to obtain the solvent composition that can dissolve the drug and specific exdpient. Therefore, experimental solubility data and computational models for trans-resveratrol could be employed in future formulation studies, such as in the design and development of dosage forms. (C) 2020 Elsevier B.V. All rights reserved.