Journal
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
Volume 144, Issue -, Pages 109-118Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.yjmcc.2020.05.013
Keywords
Mitochondria; Apoptosis; Mitochondrial permeability transition pore; ATP synthase
Categories
Funding
- National Institutes of Health, National Institute of Neurological Disorders and Stroke [NS045876, NS112706, NS081746]
- National Institutes of Aging, U.S.A [K01AG054734]
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The mitochondrial permeability transition pore (mPTP) or mitochondrial megachannel is arguably one of the most mysterious phenomena in biology today. mPTP has been at the center of ongoing extensive scientific research for the last several decades. In this review we will discuss recent advances in the field that enhance our understanding of the molecular composition of mPTP, its regulatory mechanisms and its pathophysiological role. We will describe our recent findings on the role of ATP synthase c-subunit ring as a central player in mitochondrial permeability transition and as an important metabolic regulator during development and in degenerative diseases.
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