Journal
JOURNAL OF MEDICAL VIROLOGY
Volume 93, Issue 1, Pages 424-433Publisher
WILEY
DOI: 10.1002/jmv.26224
Keywords
COVID-19; hyperinflammatory syndrome; Kawasaki disease; SARS-CoV-2
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Following the outbreak of the COVID-19 pandemic in 2020, children have been reported to develop a systemic inflammatory syndrome related to the virus. The pediatric patients mainly come from Hispanic/Latino and Black/African American backgrounds in New York City.
In December 2019, the 2019, a novel coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) first emerged in Wuhan, China. This has now spread worldwide and was declared a pandemic by March 2020. Initially, the pediatric population was described as a low risk for severe COVID-19. However, reports have emerged recently of cases of COVID-19 in children with a systemic inflammatory disease, with features that overlap with Kawasaki disease (KD). We describe the first 15 cases with the multi-systeminflammatory syndrome in children (MIS-C), temporally related to COVID-19, who presented for care to a tertiary pediatric referral center in New York City. We discuss the disproportionate burden of disease among Hispanic/Latino and Black/African American ancestry, the distinct cytokine signature across the disease spectrum (IL-1/IL-6), and the potential role and pathogenesis of SARS-CoV-2 in this new clinical entity.
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