Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 223, Issue 6, Pages 1015-1018Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiaa473
Keywords
Echinococcus multilocularis; North America; zoonosis; One Health
Categories
Funding
- Natural Sciences and Engineering Research Council of Canada
- United States National Centre for Veterinary Parasitology
- Western College of Veterinary Medicine Wildlife Health Research Fund
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The analysis confirmed AE and showed that the sequences matched infected Saskatchewan coyotes and European E3/E4 haplotypes. The patient had no travel history outside North America, suggesting autochthonous transmission of a European-type strain.
Alveolar echinococcosis (AE) is a life-threatening parasitic disease caused by the zoonotic cestode Echinococcus multilocularis. Our goals were to confirm infection, identify species, and analyze biogeographical origin of metacestode tissues from a suspected human AE case in Saskatchewan, Canada. We conducted polymerase chain reaction (PCR) targeting the nad1 mitochondrial gene for E. multilocularis and the rrnS ribosomal RNA gene for E. granulosus and conducted haplotype analysis at the nad2 locus. Our analysis confirmed AE and indicated that sequences matched infected Saskatchewan coyotes and European E3/E4 haplotypes. The patient had no travel history outside North America. This suggests autochthonous transmission of a European-type strain.
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