Journal
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
Volume 47, Issue 9-10, Pages 845-862Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s10295-020-02290-8
Keywords
Yarrowia lipolytica; Synthetic biology; Systems biology; Metabolic engineering; Biofuel; Natural products; Chemicals
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Funding
- Bill and Melinda Gates Foundation [OPP1188443]
- Cellular and Biochem Engineering Program of the National Science Foundation [1805139]
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [1805139] Funding Source: National Science Foundation
- Bill and Melinda Gates Foundation [OPP1188443] Funding Source: Bill and Melinda Gates Foundation
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Yarrowia lipolyticais an oleaginous yeast that has been substantially engineered for production of oleochemicals and drop-in transportation fuels. The unique acetyl-CoA/malonyl-CoA supply mode along with the versatile carbon-utilization pathways makes this yeast a superior host to upgrade low-value carbons into high-value secondary metabolites and fatty acid-based chemicals. The expanded synthetic biology toolkits enabled us to explore a large portfolio of specialized metabolism beyond fatty acids and lipid-based chemicals. In this review, we will summarize the recent advances in genetic, omics, and computational tool development that enables us to streamline the genetic or genomic modification forY. lipolytica.We will also summarize various metabolic engineering strategies to harness the endogenous acetyl-CoA/malonyl-CoA/HMG-CoA pathway for production of complex oleochemicals, polyols, terpenes, polyketides, and commodity chemicals. We envision thatY. lipolyticawill be an excellent microbial chassis to expand nature's biosynthetic capacity to produce plant secondary metabolites, industrially relevant oleochemicals, agrochemicals, commodity, and specialty chemicals and empower us to build a sustainable biorefinery platform that contributes to the prosperity of a bio-based economy in the future.
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