Journal
JOURNAL OF IMMUNOLOGY
Volume 205, Issue 1, Pages 202-212Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1900284
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Funding
- Ministry of Science and Technology, Taiwan [MOST 108-2321-B-016-002, MOST 107-2320-B-182-028-MY3]
- National Defense Medical Center, Ministry of National Defense-Medical Affairs Bureau Grants [MAB-106-007, MAB-107-042]
- Tri-Service General Hospital, Taipei, Taiwan [TSGH-C107-063, TSGH-C108-085]
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IgA nephropathy (IgAN), the most common primary glomerular disorder, has a relatively poor prognosis yet lacks a pathogenesis-based treatment. Compound K (CK) is a major absorbable intestinal bacterial metabolite of ginsenosides, which are bioactive components of ginseng. The present study revealed promising therapeutic effects of CK in two complementary IgAN models: a passively induced one developed by repeated injections of IgA immune complexes and a spontaneously occurring model of spontaneous grouped ddY mice. The potential mechanism for CK includes 1) inhibiting the activation of NLRP3 inflammasome in renal tissues, macrophages and bone marrow-derived dendritic cells, 2) enhancing the induction of autophagy through increased SIRT1 expression, and 3) eliciting autophagy-mediated NLRP3 inflammasome inhibition. The results support CK as a drug candidate for IgAN.
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