Journal
JOURNAL OF IMMUNOLOGY
Volume 205, Issue 2, Pages 307-312Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.2000513
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Funding
- National Institutes of Health/National Institute of Allergy and Infectious Diseases [R01AI127429, 75N93019C00051, 1R01NS111242, U19AI089992]
- Women's Health Research at Yale Pilot Project Program
- Emergent Ventures at the Mercatus Center (George Mason University, Arlington, VA)
- Mathers Foundation
- Ludwig Family Foundation
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The inflammatory response to severe acute respiratory syndrome-related coronavirus 2 infection has a direct impact on the clinical outcomes of coronavirus disease 2019 patients. Of the many innate immune pathways that are engaged by severe acute respiratory syndrome- related coronavirus 2, we highlight the importance of the inflammasome pathway. We discuss available pharmaceutical agents that target a critical component of inflammasome activation, signaling leading to cellular pyroptosis, and the downstream cytokines as a promising target for the treatment of severe coronavirus disease 2019-associated diseases.
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