Journal
JOURNAL OF HETEROCYCLIC CHEMISTRY
Volume 57, Issue 11, Pages 4057-4069Publisher
WILEY
DOI: 10.1002/jhet.4115
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In current research, pyrrolo[2,1-a]isoquinoline derivative are synthesized via a new process of four component reaction of phthalaldehyde or its derivatives, primary amines, alkyl bromides, activated acetylenic compounds and potassium fluoride/Clinoptilolite nanoparticles (KF/CP NPs) under solvent-free conditions at room temperature. Also, Dielz-Alder reactions take place in the reaction of synthesized pyrrolo[2,1-a]isoquinoline derivatives, activated acetylenic compounds and triphenylphosphine in the presence of KF/CP NPs under solvent-free conditions at room temperature. As well, antioxidation property of some prepared pyrrolo[2,1-a]isoquinolines are investigated by employing of trapping diphenyl-picrylhydrazine (DPPH) radical and ability of ferric reduction experiment. Among investigated compounds, compounds 5c have good results relative to BHT and TBHQ as standard antioxidant. Our procedure has a few benefits relative to reported method such as good rate of reaction, product with high efficiency and simple removal of catalyst from mixture of reaction. In these reactions, KF/Clinoptilolite nanoparticles show a satisfactory recyclable activity.
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