4.7 Review

Modeling neoplastic disease with spheroids and organoids

Related references

Note: Only part of the references are listed.
Review Oncology

Applications of patient-derived tumor xenograft models and tumor organoids

Go J. Yoshida

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

Article Multidisciplinary Sciences

An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity

Camilla Calandrini et al.

NATURE COMMUNICATIONS (2020)

Article Mathematical & Computational Biology

Estimation of clinical trial success rates and related parameters

Chi Heem Wong et al.

BIOSTATISTICS (2019)

Article Gastroenterology & Hepatology

Human gastric cancer modelling using organoids

Therese Seidlitz et al.

Review Pharmacology & Pharmacy

Anticancer drug discovery using multicellular tumor spheroid models

Michele Zanoni et al.

EXPERT OPINION ON DRUG DISCOVERY (2019)

Article Biotechnology & Applied Microbiology

Tubuloids derived from human adult kidney and urine for personalized disease modeling

Frans Schutgens et al.

NATURE BIOTECHNOLOGY (2019)

Review Cell Biology

Modeling Cancer with Flies and Fish

Ross L. Cagan et al.

DEVELOPMENTAL CELL (2019)

Article Biochemistry & Molecular Biology

3D model for CAR-mediated cytotoxicity using patient-derived colorectal cancer organoids

Theresa E. Schnalzger et al.

EMBO JOURNAL (2019)

Article Biochemistry & Molecular Biology

An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity

Oded Kopper et al.

NATURE MEDICINE (2019)

Article Biochemistry & Molecular Biology

ROCK2 inhibition triggers the collective invasion of colorectal adenocarcinomas

Fotine Libanje et al.

EMBO JOURNAL (2019)

Review Biochemistry & Molecular Biology

Xenograft and organoid model systems in cancer research

Margit Bleijs et al.

EMBO JOURNAL (2019)

Article Multidisciplinary Sciences

Individual brain organoids reproducibly form cell diversity of the human cerebral cortex

Silvia Velasco et al.

NATURE (2019)

Review Multidisciplinary Sciences

Cancer modeling meets human organoid technology

David Tuveson et al.

SCIENCE (2019)

Review Multidisciplinary Sciences

Organoids-on-a-chip

Sunghee Estelle Park et al.

SCIENCE (2019)

Review Oncology

Cancer Stem Cells and Radioresistance: DNA Repair and Beyond

Alexander Schulz et al.

CANCERS (2019)

Article Biochemistry & Molecular Biology

Tissue Architectural Cues Drive Organ Targeting of Tumor Cells in Zebrafish

Colin D. Paul et al.

CELL SYSTEMS (2019)

Article Multidisciplinary Sciences

Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screening

Minsuh Kim et al.

NATURE COMMUNICATIONS (2019)

Review Chemistry, Analytical

Recent Advances in Body-on-a-Chip Systems

Jong Hwan Sung et al.

ANALYTICAL CHEMISTRY (2019)

Review Biotechnology & Applied Microbiology

3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs

Ana S. Nunes et al.

BIOTECHNOLOGY AND BIOENGINEERING (2019)

Review Cell & Tissue Engineering

Constructing and Deconstructing Cancers using Human Pluripotent Stem Cells and Organoids

Ryan C. Smith et al.

CELL STEM CELL (2019)

Article Biochemistry & Molecular Biology

The Role of C-X-C Chemokine Receptor Type 4 (CXCR4) in Cell Adherence and Spheroid Formation of Human Ewing's Sarcoma Cells under Simulated Microgravity

Alexander Romswinkel et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Multidisciplinary Sciences

Human blood vessel organoids as a model of diabetic vasculopathy

Reiner A. Wimmer et al.

NATURE (2019)

Article Biochemical Research Methods

Generation of lung organoids from human pluripotent stem cells in vitro

Alyssa J. Miller et al.

NATURE PROTOCOLS (2019)

Review Oncology

Emerging organoid models: leaping forward in cancer research

Han Fan et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

Article Oncology

Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

Russell W. Jenkins et al.

CANCER DISCOVERY (2018)

Review Engineering, Biomedical

Multiorgan Microphysiological Systems for Drug Development: Strategies, Advances, and Challenges

Ying I. Wang et al.

ADVANCED HEALTHCARE MATERIALS (2018)

Article Biochemistry & Molecular Biology

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

Norman Sachs et al.

Article Biochemistry & Molecular Biology

Tumor Evolution and Drug Response in Patient-Derived Organoid Models of Bladder Cancer

Suk Hyung Lee et al.

Letter Biotechnology & Applied Microbiology

Concerns, challenges and promises of high-content analysis of 3D cellular models

Neil Carragher et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

Article Multidisciplinary Sciences

Establishment of patient-derived tumor spheroids for non-small cell lung cancer

Zengli Zhang et al.

PLOS ONE (2018)

Article Multidisciplinary Sciences

A urine-dependent human urothelial organoid offers a potential alternative to rodent models of infection

Harry Horsley et al.

SCIENTIFIC REPORTS (2018)

Article Medicine, Research & Experimental

Preclinical Models of Prostate Cancer: Patient-Derived Xenografts, Organoids, and Other Explant Models

Gail P. Risbridger et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2018)

Review Pharmacology & Pharmacy

Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning

Sigrid A. Langhans

FRONTIERS IN PHARMACOLOGY (2018)

Review Oncology

Organoid technology and applications in cancer research

Hanxiao Xu et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2018)

Article Multidisciplinary Sciences

Intra-tumour diversification in colorectal cancer at the single-cell level

Sophie F. Roerink et al.

NATURE (2018)

Review Oncology

Zebrafish: Speeding Up the Cancer Drug Discovery Process

Patricia Letrado et al.

CANCER RESEARCH (2018)

Article Biochemistry & Molecular Biology

Organoid Modeling of the Tumor Immune Microenvironment

James T. Neal et al.

Article Biochemistry & Molecular Biology

Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids

Huili Hu et al.

Article Oncology

Accelerating anticancer drug development - opportunities and trade-offs

Sharyl J. Nass et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

Review Oncology

Organoids in cancer research

Jarno Drost et al.

NATURE REVIEWS CANCER (2018)

Review Biotechnology & Applied Microbiology

Engineering Breast Cancer Microenvironments and 3D Bioprinting

Jorge A. Belgodere et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2018)

Article Immunology

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

Daniel Ohlund et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

Article Genetics & Heredity

Patient-derived xenografts undergo mouse-specific tumor evolution

Uri Ben-David et al.

NATURE GENETICS (2017)

Article Biochemistry & Molecular Biology

Human primary liver cancer-derived organoid cultures for disease modeling and drug screening

Laura Broutier et al.

NATURE MEDICINE (2017)

Article Multidisciplinary Sciences

Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids

Arianna Fumagalli et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Cell & Tissue Engineering

Modeling Stroma-Induced Drug Resistance in a Tissue-Engineered Tumor Model of Ewing Sarcoma

Marco Santoro et al.

TISSUE ENGINEERING PART A (2017)

News Item Oncology

ROS and radiotherapy: more we care

Pierre Sonveaux

ONCOTARGET (2017)

Review Genetics & Heredity

Zebrafish Xenograft: An Evolutionary Experiment in Tumour Biology

Rachael A. Wyatt et al.

GENES (2017)

Article Cell & Tissue Engineering

Differentiation of Human Induced Pluripotent Stem Cells to Mammary-like Organoids

Ying Qu et al.

STEM CELL REPORTS (2017)

Article Multidisciplinary Sciences

Breast Cancer Spheroids Reveal a Differential Cancer Stem Cell Response to Chemotherapeutic Treatment

Daniel S. Reynolds et al.

SCIENTIFIC REPORTS (2017)

Article Multidisciplinary Sciences

Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform

Aleksander Skardal et al.

SCIENTIFIC REPORTS (2017)

Article Oncology

Microfluidic device for primary tumor spheroid isolation

Jiaojiao Zhou et al.

EXPERIMENTAL HEMATOLOGY & ONCOLOGY (2017)

Review Oncology

Interrogating open issues in cancer precision medicine with patient-derived xenografts

Annette T. Byrne et al.

NATURE REVIEWS CANCER (2017)

Review Biochemistry & Molecular Biology

Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future

Nicholas McGranahan et al.

Article Nanoscience & Nanotechnology

Design and Construction of a Multi-Organ Microfluidic Chip Mimicking the in vivo Microenvironment of Lung Cancer Metastasis

Zhiyun Xu et al.

ACS APPLIED MATERIALS & INTERFACES (2016)

Review Pharmacology & Pharmacy

Human engineered heart tissue as a model system for drug testing

Alexandra Eder et al.

ADVANCED DRUG DELIVERY REVIEWS (2016)

Review Pathology

Organoids as Models for Neoplastic Transformation

James T. Neal et al.

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 11 (2016)

Review Biotechnology & Applied Microbiology

3D tumor spheroids: an overview on the tools and techniques used for their analysis

Elisabete C. Costa et al.

BIOTECHNOLOGY ADVANCES (2016)

Review Oncology

In vitro models of cancer stem cells and clinical applications

Sara S. Franco et al.

BMC CANCER (2016)

Review Biochemistry & Molecular Biology

Modeling Development and Disease with Organoids

Hans Clevers

Review Cell Biology

Organoids: Modeling Development and the Stem Cell Niche in a Dish

Kai Kretzschmar et al.

DEVELOPMENTAL CELL (2016)

Article Biochemistry & Molecular Biology

In vitro and in vivo antitumor effects of the VO-chrysin complex on a new three-dimensional osteosarcoma spheroids model and a xenograft tumor in mice

Ignacio E. Leon et al.

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY (2016)

Review Biochemical Research Methods

A practical guide to hydrogels for cell culture

Steven R. Caliari et al.

NATURE METHODS (2016)

Review Cell & Tissue Engineering

Polymeric Biomaterials for In Vitro Cancer Tissue Engineering and Drug Testing Applications

Shantanu Pradhan et al.

TISSUE ENGINEERING PART B-REVIEWS (2016)

Article Oncology

Patient-derived xenograft (PDX) tumors increase growth rate with time

Alexander T. Pearson et al.

ONCOTARGET (2016)

Article Oncology

Aldehyde dehydrogenases in cancer stem cells: potential as therapeutic targets

David W. Clark et al.

ANNALS OF TRANSLATIONAL MEDICINE (2016)

Review Pathology

Engineered In Vitro Disease Models

Kambez H. Benam et al.

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 10 (2015)

Article Biochemistry & Molecular Biology

Modeling Familial Cancer with Induced Pluripotent Stem Cells

Dung-Fang Lee et al.

Article Biochemistry & Molecular Biology

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

Meritxell Huch et al.

Article Biochemistry & Molecular Biology

Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

Marc van de Wetering et al.

Article Biochemistry & Molecular Biology

Organoid Models of Human and Mouse Ductal Pancreatic Cancer

Sylvia F. Boj et al.

Article Medicine, Research & Experimental

Intra- and inter-tumor heterogeneity in a vemurafenib-resistant melanoma patient and derived xenografts

Kristel Kemper et al.

EMBO MOLECULAR MEDICINE (2015)

Article Biotechnology & Applied Microbiology

Impact of the spheroid model complexity on drug response

Oliver Ingo Hoffmann et al.

JOURNAL OF BIOTECHNOLOGY (2015)

Article Multidisciplinary Sciences

Sequential cancer mutations in cultured human intestinal stem cells

Jarno Drost et al.

NATURE (2015)

Article Biochemistry & Molecular Biology

Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids

Mami Matano et al.

NATURE MEDICINE (2015)

Review Pharmacology & Pharmacy

In vitro human cell line models to predict clinical response to anticancer drugs

Nifang Niu et al.

PHARMACOGENOMICS (2015)

Article Multidisciplinary Sciences

Flow perfusion effects on three-dimensional culture and drug sensitivity of Ewing sarcoma

Marco Santoro et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Cell Biology

Beyond 3D culture models of cancer

Kandice Tanner et al.

SCIENCE TRANSLATIONAL MEDICINE (2015)

Article Medicine, Research & Experimental

Construction of orthotopic xenograft mouse models for human pancreatic cancer

Lei Dai et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2015)

Article Oncology

Spherical Cancer Models in Tumor Biology

Louis-Bastien Weiswald et al.

NEOPLASIA (2015)

Article Multidisciplinary Sciences

Fibroblasts Influence Survival and Therapeutic Response in a 3D Co-Culture Model

Meher Majety et al.

PLOS ONE (2015)

Review Oncology

Tumorigenesis: it takes a village

Doris P. Tabassum et al.

NATURE REVIEWS CANCER (2015)

Article Engineering, Biomedical

Bioengineered human tumor within a bone niche

Aranzazu Villasante et al.

BIOMATERIALS (2014)

Article Biotechnology & Applied Microbiology

Optimization of Liquid Overlay Technique to Formulate Heterogenic 3D Co-Cultures Models

Elisabete C. Costa et al.

BIOTECHNOLOGY AND BIOENGINEERING (2014)

Article Biochemistry & Molecular Biology

Organoid Cultures Derived from Patients with Advanced Prostate Cancer

Dong Gao et al.

Article Biochemistry & Molecular Biology

Identification of Multipotent Luminal Progenitor Cells in Human Prostate Organoid Cultures

Wouter R. Karthaus et al.

Review Pharmacology & Pharmacy

Approaches to in vitro tissue regeneration with application for human disease modeling and drug development

Mohammad R. Ebrahimkhani et al.

DRUG DISCOVERY TODAY (2014)

Article Biotechnology & Applied Microbiology

An in vitro osteosarcoma 3D microtissue model for drug development

Markus Rimann et al.

JOURNAL OF BIOTECHNOLOGY (2014)

Article Biotechnology & Applied Microbiology

Growth of osteosarcoma cells in a three-dimensional bone-like matrix alters their susceptibility to adeno-associated virus

Sangeeta Dey et al.

JOURNAL OF GENERAL VIROLOGY (2014)

Article Multidisciplinary Sciences

Modelling human development and disease in pluripotent stem-cell-derived gastric organoids

Kyle W. McCracken et al.

NATURE (2014)

Article Biotechnology & Applied Microbiology

Tackling the cancer stem cells - what challenges do they pose?

Diwakar R. Pattabiraman et al.

NATURE REVIEWS DRUG DISCOVERY (2014)

Article Oncology

Acidity Generated by the Tumor Microenvironment Drives Local Invasion

Veronica Estrella et al.

CANCER RESEARCH (2013)

Article Biochemistry & Molecular Biology

Collective Invasion in Breast Cancer Requires a Conserved Basal Epithelial Program

Kevin J. Cheung et al.

Review Biochemistry & Molecular Biology

DNA-Damaging Agents in Cancer Chemotherapy: Serendipity and Chemical Biology

Kahlin Cheung-Ong et al.

CHEMISTRY & BIOLOGY (2013)

Review Pharmacology & Pharmacy

Three-dimensional cell culture: the missing link in drug discovery

Susan Breslin et al.

DRUG DISCOVERY TODAY (2013)

Article Medicine, Research & Experimental

New chondrosarcoma cell lines and mouse models to study the link between chondrogenesis and chemoresistance

David Monderer et al.

LABORATORY INVESTIGATION (2013)

Review Multidisciplinary Sciences

Influence of tumour micro-environment heterogeneity on therapeutic response

Melissa R. Junttila et al.

NATURE (2013)

Review Biochemistry & Molecular Biology

Microenvironmental regulation of tumor progression and metastasis

Daniela F. Quail et al.

NATURE MEDICINE (2013)

Review Biotechnology & Applied Microbiology

The role of tumour-stromal interactions in modifying drug response: challenges and opportunities

Douglas W. McMillin et al.

NATURE REVIEWS DRUG DISCOVERY (2013)

Article Oncology

In vitro irradiation system for radiobiological experiments

Anna Tesei et al.

RADIATION ONCOLOGY (2013)

Article Multidisciplinary Sciences

Modeling Ewing sarcoma tumors in vitro with 3D scaffolds

Eliza Li Shan Fong et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Oncology

Mechanisms of chemoresistance in cancer stem cells

Lissa Nurrul Abdullah et al.

CLINICAL AND TRANSLATIONAL MEDICINE (2013)

Review Oncology

Zebrafish cancer: the state of the art and the path forward

Richard White et al.

NATURE REVIEWS CANCER (2013)

Article Cell Biology

Zebrafish xenografts as a tool for in vivo studies on human cancer

Martina Konantz et al.

HEMATOPOIETIC STEM CELLS VIII (2012)

Review Pharmacology & Pharmacy

The tumor microenvironment is a dominant force in multidrug resistance

Ana Luisa Correia et al.

DRUG RESISTANCE UPDATES (2012)

Article Engineering, Biomedical

Incorporation of exudates of human platelet-rich fibrin gel in biodegradable fibrin scaffolds for tissue engineering of cartilage

Chi-Sheng Chien et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2012)

Article Cell Biology

The tumor microenvironment at a glance

Frances R. Balkwill et al.

JOURNAL OF CELL SCIENCE (2012)

Article Cell Biology

Deconstructing the third dimension - how 3D culture microenvironments alter cellular cues

Brendon M. Baker et al.

JOURNAL OF CELL SCIENCE (2012)

Article Cell Biology

The proliferation rate paradox in antimitotic chemotherapy

Timothy J. Mitchison

MOLECULAR BIOLOGY OF THE CELL (2012)

Review Cell Biology

The Xenopus oocyte: A model for studying the metabolic regulation of cancer cell death

Leta K. Nutt

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2012)

Review Oncology

Cancer stem cell definitions and terminology: the devil is in the details

Peter Valent et al.

NATURE REVIEWS CANCER (2012)

Review Immunology

Humanized mice for immune system investigation: progress, promise and challenges

Leonard D. Shultz et al.

NATURE REVIEWS IMMUNOLOGY (2012)

Review Cell & Tissue Engineering

Eyes Wide Open: A Critical Review of Sphere-Formation as an Assay for Stem Cells

Erika Pastrana et al.

CELL STEM CELL (2011)

Article Oncology

Glioblastoma-derived spheroid cultures as an experimental model for analysis of EGFR anomalies

Monika Witusik-Perkowska et al.

JOURNAL OF NEURO-ONCOLOGY (2011)

Review Medicine, Research & Experimental

Drug Resistance and Cellular Adaptation to Tumor Acidic pH Microenvironment

Jonathan W. Wojtkowiak et al.

MOLECULAR PHARMACEUTICS (2011)

Review Multidisciplinary Sciences

Cancer immunotherapy comes of age

Ira Mellman et al.

NATURE (2011)

Review Biochemistry & Molecular Biology

The cancer stem cell: premises, promises and challenges

Hans Clevers

NATURE MEDICINE (2011)

Editorial Material Oncology

High drug attrition rates-where are we going wrong?

Lisa Hutchinson et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2011)

Article Biotechnology & Applied Microbiology

Advances in the preclinical testing of cancer therapeutic hypotheses

Giordano Caponigro et al.

NATURE REVIEWS DRUG DISCOVERY (2011)

Review Oncology

Cell lineage and cell death: Caenorhabditis elegans and cancer research

Malia B. Potts et al.

NATURE REVIEWS CANCER (2011)

Article Oncology

Guidelines for the welfare and use of animals in cancer research

P. Workman et al.

BRITISH JOURNAL OF CANCER (2010)

Review Cell Biology

Tumors as Organs: Complex Tissues that Interface with the Entire Organism

Mikala Egeblad et al.

DEVELOPMENTAL CELL (2010)

Review Biochemistry & Molecular Biology

Three-dimensional culture of hepatocytes for prediction of drug-induced hepatotoxicity

Qin Meng

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2010)

Article Biotechnology & Applied Microbiology

Multicellular tumor spheroids: An underestimated tool is catching up again

Franziska Hirschhaeuser et al.

JOURNAL OF BIOTECHNOLOGY (2010)

Article Biochemistry & Molecular Biology

Tumor cell-specific bioluminescence platform to identify stroma-induced changes to anticancer drug activity

Douglas W. McMillin et al.

NATURE MEDICINE (2010)

Review Multidisciplinary Sciences

The cancer genome

Michael R. Stratton et al.

NATURE (2009)

Article Biochemical Research Methods

Spheroid-based drug screen: considerations and practical approach

Juergen Friedrich et al.

NATURE PROTOCOLS (2009)

Review Biotechnology & Applied Microbiology

Tumour-initiating cells: challenges and opportunities for anticancer drug discovery

Bin-Bing S. Zhou et al.

NATURE REVIEWS DRUG DISCOVERY (2009)

Review Biochemistry & Molecular Biology

Catch of the day: zebrafish as a human cancer model

K. Stoletov et al.

ONCOGENE (2008)

Review Biochemistry & Molecular Biology

Cadherins and cancer: how does cadherin dysfunction promote tumor progression?

A. Jeanes et al.

ONCOGENE (2008)

Review Oncology

Drug resistance and the solid tumor microenvironment

Olivier Tredan et al.

JOURNAL OF THE NATIONAL CANCER INSTITUTE (2007)

Review Biochemistry & Molecular Biology

Modeling tissue morphogenesis and cancer in 3D

Kenneth M. Yamada et al.

Article Biochemical Research Methods

Three-dimensional culture models of normal and malignant breast epithelial cells

Genee Y. Lee et al.

NATURE METHODS (2007)

Review Biology

Experimental anti-tumor therapy in 3-D: Spheroids - old hat or new challenge?

Juergen Friedrich et al.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2007)

Review Oncology

Drug penetration in solid tumours

Andrew I. Minchinton et al.

NATURE REVIEWS CANCER (2006)

Article Biotechnology & Applied Microbiology

What's wrong with our cancer models?

A Kamb

NATURE REVIEWS DRUG DISCOVERY (2005)

Article Multidisciplinary Sciences

tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors

S Berghmans et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Review Biochemical Research Methods

The use of 3-D cultures for high-throughput screening: The multicellular spheroid model

LA Kunz-Schughart et al.

JOURNAL OF BIOMOLECULAR SCREENING (2004)

Article Biotechnology & Applied Microbiology

Three-dimensional cellular development is essential for ex vivo formation of human bone

S Kale et al.

NATURE BIOTECHNOLOGY (2000)