4.7 Review

Targeting immune checkpoints in hematological malignancies

Related references

Note: Only part of the references are listed.
Article Oncology

A phase 1b study of dual PD-1 and CTLA-4 or KIR blockade in patients with relapsed/refractory lymphoid malignancies

Philippe Armand et al.

Summary: This study examined the safety and efficacy of combining PD-1 blockade with other pathways inhibitors in lymphoid malignancies. While some combinations showed effectiveness in cHL patients, overall, the combinations did not significantly improve upon the efficacy of single-agent nivolumab in the diseases studied.

LEUKEMIA (2021)

Review Immunology

Myeloid immunosuppression and immune checkpoints in the tumor microenvironment

Kyohei Nakamura et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2020)

Article Biochemistry & Molecular Biology

PD-1 Imposes Qualitative Control of Cellular Transcriptomes in Response to T Cell Activation

Kenji Shimizu et al.

MOLECULAR CELL (2020)

Article Medicine, General & Internal

KTE-X19 CAR T-Cell Therapy in Relapsed or Refractory Mantle-Cell Lymphoma

Michael Wang et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Review Biochemistry & Molecular Biology

Genomic correlates of response to immune checkpoint blockade

Tanya E. Keenan et al.

NATURE MEDICINE (2019)

Article Medicine, Research & Experimental

Blocking expression of inhibitory receptor NKG2A overcomes tumor resistance to NK cells

Takahiro Kamiya et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Review Oncology

Immune checkpoint blockade and CAR-T cell therapy in hematologic malignancies

Hao Wang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

Article Multidisciplinary Sciences

CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy

Amira A. Barkal et al.

NATURE (2019)

Review Pharmacology & Pharmacy

A Review of Efficacy and Safety of Checkpoint Inhibitor for the Treatment of Acute Myeloid Leukemia

Dan Liao et al.

FRONTIERS IN PHARMACOLOGY (2019)

Article Biochemistry & Molecular Biology

Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3

Jun Wang et al.

Article Medicine, General & Internal

Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma

Stephen J. Schuster et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Medicine, Research & Experimental

Early alterations in stem-like/marrow-resident T cells and innate and myeloid cells in preneoplastic gammopathy

Jithendra Kini Bailur et al.

JCI INSIGHT (2019)

Review Oncology

Phagocytosis checkpoints as new targets for cancer immunotherapy

Mingye Feng et al.

NATURE REVIEWS CANCER (2019)

Review Oncology

Chimeric antigen receptor T-cell therapy - assessment and management of toxicities

Sattva S. Neelapu et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

Article Medicine, Research & Experimental

Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade-mediated tumor regression

Heng Lin et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Article Oncology

Activity of pembrolizumab in relapsed/refractory NK/T-cell lymphoma

Xin Li et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2018)

Letter Medicine, General & Internal

Rapid Progression of Adult T-Cell Leukemia-Lymphoma after PD-1 Inhibitor Therapy

Lee Ratner et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Cell Biology

Oncogenic JAK2V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms

Alessandro Prestipino et al.

SCIENCE TRANSLATIONAL MEDICINE (2018)

Article Oncology

PD-L1 Binds to B7-1 Only In Cis on the Same Cell Surface

Apoorvi Chaudhri et al.

CANCER IMMUNOLOGY RESEARCH (2018)

Article Biotechnology & Applied Microbiology

Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo

Sarwish Rafiq et al.

NATURE BIOTECHNOLOGY (2018)

Review Oncology

Fundamental Mechanisms of Immune Checkpoint Blockade Therapy

Spencer C. Wei et al.

CANCER DISCOVERY (2018)

Article Medicine, General & Internal

Immune Escape of Relapsed AML Cells after Allogeneic Transplantation

M. J. Christopher et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Medicine, General & Internal

CD47 Blockade by Hu5F9-G4 and Rituximab in Non-Hodgkin's Lymphoma

Ranjana Advani et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Oncology

Clinical assessment of immune-related adverse events

Aaron Sosa et al.

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY (2018)

Review Hematology

PD-1 expression and clinical PD-1 blockade in B-cell lymphomas

Zijun Y. Xu-Monette et al.

BLOOD (2018)

Review Hematology

Redirecting T cells to hematological malignancies with bispecific antibodies

Mireya Paulina Velasquez et al.

BLOOD (2018)

Review Hematology

Emerging treatments for classical myeloproliferative neoplasms

Alessandro M. Vannucchi et al.

BLOOD (2017)

Review Immunology

LAG3 (CD223) as a cancer immunotherapy target

Lawrence P. Andrews et al.

IMMUNOLOGICAL REVIEWS (2017)

Article Oncology

Tumor Mutational Burden as an Independent Predictor of Response to Immunotherapy in Diverse Cancers

Aaron M. Goodman et al.

MOLECULAR CANCER THERAPEUTICS (2017)

Article Biotechnology & Applied Microbiology

Long-Duration Complete Remissions of Diffuse Large B Cell Lymphoma after Anti-CD19 Chimeric Antigen Receptor T Cell Therapy

James N. Kochenderfer et al.

MOLECULAR THERAPY (2017)

Article Multidisciplinary Sciences

PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis

Tim Wartewig et al.

NATURE (2017)

Article Medicine, General & Internal

Overall Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma

J. D. Wolchok et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Medicine, General & Internal

Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma

S. S. Neelapu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Multidisciplinary Sciences

Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent

Alice O. Kamphorst et al.

SCIENCE (2017)

Review Immunology

TIGIT: A Key Inhibitor of the Cancer Immunity Cycle

Nicholas A. Manieri et al.

TRENDS IN IMMUNOLOGY (2017)

Article Multidisciplinary Sciences

Armored CAR T cells enhance antitumor efficacy and overcome the tumor microenvironment

Oladapo O. Yeku et al.

SCIENTIFIC REPORTS (2017)

Article Medicine, Research & Experimental

Fine and Predictable Tuning of TALEN Gene Editing Targeting for Improved T Cell Adoptive Immunotherapy

Anne-Sophie Gautron et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2017)

Article Oncology

Molecular Pathways: Targeting CD96 and TIGIT for Cancer Immunotherapy

Stephen J. Blake et al.

CLINICAL CANCER RESEARCH (2016)

Article Medicine, Research & Experimental

Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition

Leonid Cherkassky et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Article Oncology

PD-L1 and PD-L2 Genetic Alterations Define Classical Hodgkin Lymphoma and Predict Outcome

Margaretha G. M. Roemer et al.

JOURNAL OF CLINICAL ONCOLOGY (2016)

Article Immunology

Identification of CD112R as a novel checkpoint for human T cells

Yuwen Zhu et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2016)

Review Immunology

Targeting natural killer cells in cancer immunotherapy

Camille Guillerey et al.

NATURE IMMUNOLOGY (2016)

Review Oncology

Driving CAR T-cells forward

Hollie J. Jackson et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2016)

Review Oncology

Safety profiles of anti-CTLA-4 and anti-PD-1 antibodies alone and in combination

Celine Boutros et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2016)

Article Medicine, General & Internal

Ipilimumab for Patients with Relapse after Allogeneic Transplantation

Matthew S. Davids et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Medicine, Research & Experimental

TIGIT predominantly regulates the immune response via regulatory T cells

Sema Kurtulus et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Biotechnology & Applied Microbiology

Enhancing Antitumor Efficacy of Chimeric Antigen Receptor T Cells Through Constitutive CD40L Expression

Kevin J. Curran et al.

MOLECULAR THERAPY (2015)

Article Biochemistry & Molecular Biology

CD47 blockade triggers T cell-mediated destruction of immunogenic tumors

Xiaojuan Liu et al.

NATURE MEDICINE (2015)

Article Medicine, General & Internal

PD-1 Blockade with Nivolumab in Relapsed or Refractory Hodgkin's Lymphoma

Stephen M. Ansell et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Review Oncology

Epstein-Barr Virus-Associated Lymphomas

Ewelina Grywalska et al.

SEMINARS IN ONCOLOGY (2015)

Article Medicine, General & Internal

Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia

Shannon L. Maude et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Oncology

Tim-3: An Emerging Target in the Cancer Immunotherapy Landscape

Ana C. Anderson

CANCER IMMUNOLOGY RESEARCH (2014)

Review Oncology

The tumour microenvironment in B cell lymphomas

David W. Scott et al.

NATURE REVIEWS CANCER (2014)

Article Medicine, General & Internal

Somatic Mutations of Calreticulin in Myeloproliferative Neoplasms

Thorsten Klampfl et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Medical Laboratory Technology

CD80 (B7.1) is expressed on both malignant B cells and nonmalignant stromal cells in non-Hodgkin lymphoma

Naveen Dakappagari et al.

CYTOMETRY PART B-CLINICAL CYTOMETRY (2012)

Article Biochemistry & Molecular Biology

Constitutive Clathrin-mediated Endocytosis of CTLA-4 Persists during T Cell Activation

Omar S. Qureshi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Immunology

Cutting Edge: CTLA-4 on Effector T Cells Inhibits In Trans

Emily Corse et al.

JOURNAL OF IMMUNOLOGY (2012)

Article Medicine, General & Internal

Safety and Activity of Anti-PD-L1 Antibody in Patients with Advanced Cancer

Julie R. Brahmer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Article Medicine, General & Internal

Safety, Activity, and Immune Correlates of Anti-PD-1 Antibody in Cancer

Suzanne L. Topalian et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Article Medicine, General & Internal

Inducible Apoptosis as a Safety Switch for Adoptive Cell Therapy

Antonio Di Stasi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

Article Cell & Tissue Engineering

TIM-3 Is a Promising Target to Selectively Kill Acute Myeloid Leukemia Stem Cells

Yoshikane Kikushige et al.

CELL STEM CELL (2010)

Article Immunology

Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

Kaori Sakuishi et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2010)

Article Medicine, General & Internal

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

F. Stephen Hodi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Article Multidisciplinary Sciences

Dual function of CTLA-4 in regulatory T cells and conventional T cells to prevent multiorgan autoimmunity

Nitya Jain et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Immunology

CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance

Randall H. Friedline et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2009)

Article Multidisciplinary Sciences

CTLA-4 control over Foxp3+ regulatory T cell function

Kajsa Wing et al.

SCIENCE (2008)

Article Medicine, Research & Experimental

LAG-3 regulates CD8+T cell accumulation and effector function in murine self- and tumor-tolerance systems

Joseph F. Grosso et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

Review Immunology

Self-tolerance of natural killer cells

David H. Raulet et al.

NATURE REVIEWS IMMUNOLOGY (2006)

Review Immunology

The SIRP family of receptors and immune regulation

AN Barclay et al.

NATURE REVIEWS IMMUNOLOGY (2006)

Article Immunology

PD-L2 is a second ligand for PD-I and inhibits T cell activation

Y Latchman et al.

NATURE IMMUNOLOGY (2001)