Journal
JOURNAL OF HEMATOLOGY & ONCOLOGY
Volume 13, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s13045-020-00932-z
Keywords
Tissue factor; Protease-activated receptors; Receptor tyrosine kinases; Integrins; Metastasis; Angiogenesis
Categories
Funding
- National Institutes of Health (NIH) [F32CA216996]
- NIH [R01NS102669, R01NS117104]
- Northwestern University SPORE in Brain Cancer [P50CA221747]
- Lou and Jean Malnati Brain Tumor Institute
Ask authors/readers for more resources
Tissue factor (TF) is the primary initiator of the coagulation cascade, though its effects extend well beyond hemostasis. When TF binds to Factor VII, the resulting TF:FVIIa complex can proteolytically cleave transmembrane G protein-coupled protease-activated receptors (PARs). In addition to activating PARs, TF:FVIIa complex can also activate receptor tyrosine kinases (RTKs) and integrins. These signaling pathways are utilized by tumors to increase cell proliferation, angiogenesis, metastasis, and cancer stem-like cell maintenance. Herein, we review in detail the regulation of TF expression, mechanisms of TF signaling, their pathological consequences, and how it is being targeted in experimental cancer therapeutics.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available