Journal
JOURNAL OF GENERAL VIROLOGY
Volume 101, Issue 10, Pages 1079-1084Publisher
MICROBIOLOGY SOC
DOI: 10.1099/jgv.0.001466
Keywords
transmissible gastroenteritis virus; curcumin; inhibition assay; virucidal assay
Categories
Funding
- National Science Foundation of China [31972692, 31402181]
- Hubei Provincial Natural Science Foundation of China [2018CFB662]
- science and technology research project of Hubei Provincial Department of Education of China
Ask authors/readers for more resources
Emerging coronaviruses represent serious threats to human and animal health worldwide, and no approved therapeutics are currently available. Here, we used Transmissible gastroenteritis virus (TGEV) as the alpha-coronavirus model, and investigated the antiviral properties of curcumin against TGEV. Our results demonstrated that curcumin strongly inhibited TGEV proliferation and viral protein expression in a dose-dependent manner. We also observed that curcumin exhibited direct virucidal abilities in a dose-, temperature- and time-dependent manner. Furthermore, time-of-addition assays showed that curcumin mainly acted in the early phase of TGEV replication. Notably, in an adsorption assay, curcumin at 40 mu M resulted in a reduction in viral titres of 3.55 log TCID50 ml(-1), indicating that curcumin possesses excellent inhibitory effects on the adsorption of TGEV. Collectively, we demonstrate for the first time that curcumin has virucidal activity and virtual inhibition against TGEV, suggesting that curcumin might be a candidate drug for effective control of TGEV infection.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available