DNA damage and genetic aberration inducedviadifferent sized silver nanoparticles: Therapeutic approaches ofCasimiroa edulisandGlycosmis pentaphyllaleaves extracts

Potential ofCasimiroa edulisandGlycosmis pentaphyllaleaves extracts were investigated against the effect of two different particle sizes of silver nanoparticles induced toxicity in mice. Mice received silver nanoparticles (AgNPs) (100 mg/kg) with 20 and 100 nm for four weeks followed by daily oral dose of extracts (500 mg/kg) for three weeks.C. edulisleaves identified fourteen phenolic compounds while,G. pentaphyllaleaves identified, twelve phenolic compounds. Additionally, biochemical, genotoxicity, mutagenicity, and histopathological investigations were carried out, revealed that liver function activities, lipid profile, hydrogen peroxide, and C-reactive protein were significantly elevate post AgNPs exposure. While, superoxide dismutase, glutathione-S-transferases, and glutathione peroxidase significantly reduce. A marked amelioration in all detected biomarkers, improved histopathological changes and repair DNA damage after treated withC. edulisandG. pentaphyllaleaves extracts. These extracts are used for the first time as promising candidate therapeutic agents against toxicity induced by AgNPs. Practical applications The potential applications of AgNPs make it necessary to investigate the possible toxicity associated with release of free silver ions in the biological system. AgNPs of varying particle sizes had toxic effects as evidenced by alterations in some cellular biochemical parameters, genotoxicity, mutagenicity, and histopathological indices on mice.Casimiroa edulisandGlycosmis pentaphyllaleaves extracts are used for the first time as promising candidate therapeutic, where they are able to ameliorate the toxicity induced via AgNPs and record vacillate percentage of improvement in the selected biomarkers, as a result of the bioactive secondary metabolites especially flavonoids and other polyphenolic compounds.