Journal
JOURNAL OF DERMATOLOGICAL TREATMENT
Volume 33, Issue 2, Pages 885-896Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09546634.2020.1789043
Keywords
Mometasone furoate; vesicles; aspasomes; ascorbyl palmitate; psoriasis; carbopol
Categories
Ask authors/readers for more resources
The developed Mometasone Furoate aspasomal gel showed high entrapment efficiency and sustained drug release, with no irritation or inflammation on the skin, presenting a new approach for the treatment of psoriasis.
Background Present investigation was aimed to develop aspasomal gel of Mometasone Furoate for the treatment of Psoriasis that are biologically active and deliver drug at controlled rate and decrease dosing frequency. Methods The vesicles were fabricated using film hydration method and optimized using 32 factorial Design. Prepared formulations were evaluated for percent drug loading, vesicle size, Zeta potential, polydispersity index and morphological studies. Gel was prepared using carbopol by loading optimized drug loaded asposomes and was evaluated for drug content, pH, viscosity and spreadability. The drug release study from the gel was done using dialysis membrane and goat skin. Anti- oxidant potency of the prepared aspasomal gel was determined by Ferric Reducing Assay whereas, in-vivo performance for inflammation and skin irritation was carried out using Wistar rats. Results Optimized aspasomes demonstrated desired properties for entrapment efficiency (74.72 +/- 1.8), vesicle size (282.9 +/- 1.7), polydispersity index (0.2), zeta potential (-20.2 mV) with spherical shape. The results recorded for drug release from the optimized aspasomal gel exhibited sustained release (24h) compared to the marketed cream (5h). Depot formation of Mometasone furoate loaded aspasomal gel in the epidermis was confirmed by ex vivo skin penetration study by using fluorescent marker. In-vivo study revealed no any irritation and inflammation to the skin promoting drug delivery system to treat psoriasis. Conclusion In conclusion, Mometasone furoate loaded aspasomal gel releases the drug for longer duration of time and reduce dosing frequency, providing the new dimension for the treatment of psoriasis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available