Journal
JOURNAL OF DERMATOLOGICAL TREATMENT
Volume 33, Issue 2, Pages 1107-1110Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09546634.2020.1782816
Keywords
Plaque psoriasis; psoriatic arthritis; paradoxical psoriasis; secukinumab
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This case report describes the varied response of a patient with plaque psoriasis and psoriatic arthritis to treatment-interruption and re-treatment with the IL-17A blocking antibody secukinumab.
This case report describes a patient with plaque psoriasis and psoriatic arthritis who experienced IL-17A blocking antibody secukinumab treatment-interruption followed by re-treatment. The patient showed heterogeneous responses; significant improvement at initial introduction of secukinumab with rapid deterioration after discontinuation, followed by worsening symptoms and pustular eruption with reintroduction, and skin clearance after dose escalation.
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