Journal
JOURNAL OF CROHNS & COLITIS
Volume 15, Issue 2, Pages 203-211Publisher
OXFORD UNIV PRESS
DOI: 10.1093/ecco-jcc/jjaa146
Keywords
Inflammatory bowel disease; Crohn's disease; ulcerative colitis; chronic diarrhoea; abdominal pain; gastrointestinal symptoms; irritable bowel syndrome; depression; diagnosis; delayed diagnosis
Categories
Funding
- Living with IBD Research Programme at Crohn's Colitis UK [SP2018/3]
- Wellcome Trust Institute Strategic Support Fund [ISSF] grant
- National Institute of Health Research Biomedical Research Centre at the Maudsley
- National Institute for Health Research [NIHR] School for Public Health Research [SPHR]
- NIHR Northwest London Applied Research Collaboration [ARC]
- Imperial NIHR Biomedical Research Centre
- NIHR Biomedical Research Centre funding scheme
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The study revealed a higher prevalence of gastrointestinal symptoms in patients diagnosed with IBD compared to the background population, potentially due to undiagnosed diseases. Patients with prior diagnoses of irritable bowel syndrome (IBS) or depression were less likely to receive timely specialist review. Enhanced pathways are needed to expedite specialist referrals and timely IBD diagnosis.
Background and Aims: Lack of timely referral and significant waits for specialist review amongst individuals with unresolved gastrointestinal [GI] symptoms can result in delayed diagnosis of inflammatory bowel disease [IBD]. Aims: To determine the frequency and duration of GI symptoms and predictors of timely specialist review before the diagnosis of both Crohn's disease [CD] and ulcerative colitis [UC]. Methods: This is a case control study of IBD matched 1:4 for age and sex to controls without IBD using the Clinical Practice Research Datalink from 1998 to 2016. Results: We identified 19 555 cases of IBD and 78 114 controls. One in four cases of IBD reported GI symptoms to their primary care physician more than 6 months before receiving a diagnosis. There was a significant excess prevalence of GI symptoms in each of the 10 years before IBD diagnosis. GI symptoms were reported by 9.6% and 10.4% at 5 years before CD and UC diagnosis respectively compared to 5.8% of controls. Amongst patients later diagnosed with IBD, <50% received specialist review within 18 months from presenting with chronic GI symptoms. Patients with a previous diagnosis of irritable bowel syndrome [IBS] or depression were less likely to receive timely specialist review (IBS: hazard ratio [HR] = 0.77, 95% confidence interval [CI] 0.60-0.99, depression: HR = 0.77, 95% CI 0.60-0.98). Conclusions: There is an excess of GI symptoms 5 years before diagnosis of IBD compared to the background population, probably attributable to undiagnosed disease. Previous diagnoses of IBS and depression are associated with delays in specialist review. Enhanced pathways are needed to accelerate specialist referral and timely IBD diagnosis.
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