Journal
JOURNAL OF CONTROLLED RELEASE
Volume 324, Issue -, Pages 124-133Publisher
ELSEVIER
DOI: 10.1016/j.jconrel.2020.05.008
Keywords
Supramolecular chemotherapy; Drug delivery; Macrocyclic amphiphiles; Calixarene; Molecular recognition
Funding
- NSFC [51873090, 31961143004]
- Fundamental Research Funds for the Central Universities
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Supramolecular chemotherapy is currently a new strategy to improve the therapeutic efficacy as well as overcome the side effects of traditional chemotherapy. Herein, a supramolecular chemotherapy platform based on the pegylated guanidinium-modified calix[5]arene pentadodecyl ether (GC5A-12C) nanoassembly was prepared. Three commercially available antitumor drugs: oxaliplatin, methotrexate and chlorambucil, all showed strong binding to this GC5A-12C nanocarrier. The supramolecular nanodrugs achieved higher anticancer performances compared with free drugs in cell experiments. Furthermore, the cellular uptake mechanisms and efficacy are confirmed by fluorescence imaging.
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