Journal
JOURNAL OF COMPARATIVE PATHOLOGY
Volume 178, Issue -, Pages 16-21Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jcpa.2020.06.004
Keywords
dog; galectin-3; immunohistochemistry; squamous cell carcinoma
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Funding
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2013/13252-8, 2016/16239-0, 2016/03862-1]
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Squamous cell carcinoma (SCC) is a frequent malignant neoplasm of the skin that usually arises from areas of solar dermatosis. It is characterized by local invasiveness and regional lymph node metastasis, mainly in poorly differentiated tumours. Galectin-3 (Gal-3) is a lectin that is expressed in the nucleus or cytoplasm and has been identified as a prognostic tool for human neoplasms. The purpose of this study was to characterize Gal-3 expres-sion in canine cutaneous SCCs and to investigate its relationship with tumour differentiation and cell prolifer-ation indices. Immunohistochemical analysis of 50 SCCs for Gal-3 revealed no correlation between the localization or intensity of immunolabelling, or number of immunopositive cells, with histological grade of tumour or proliferative activity. The results suggest that Gal-3 expression is not a reliable prognostic marker for cutaneous SCC in dogs. (C) 2020 Elsevier Ltd. All rights reserved.
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