Design and Preparation of Silver-Copper Nanoalloys for Antibacterial Applications

The search for new more effective nanoparticles based antimicrobial agents has been under way in recent decades. Silver nanoparticles are hydrophobic and have a negative charge. We report on the preparation of Ag-Cu bimetallic nanoparticles with various silver contents synthesized by electric explosion of two twisted wires of the metals in argon atmosphere. The method allows to obtain nanoparticles of a given composition, has high performance and scalability. Nanoparticles were investigated using X-ray diffraction, high-resolution transmission electron microscopy, energy dispersive analysis and microelectrophoresis techniques. We evaluated the antibacterial activity of the nanoparticles against Gram-negativeE. coliand Gram-positive methicillin resistanceS. aureusMRSA. Our study showed that the synthesized nanoparticles have a positive zeta potential of about 30 mV at pH 7.2 and high antimicrobial activity against the tested bacteria strains, which is close to the activity of silver nanoparticles with a size of 20 nm. The high antimicrobial activity of the nanoparticles is due to the prolonged slow release of silver and copper ions, which makes nanoalloys more effective than Cu and Ag metallic nanoparticles. The synthesized nanoparticles have high antimicrobial activity and demonstrate the potential for their use as promising new generation antibacterial agents effective against resistant microorganisms.

Automated summary

The study successfully synthesized Ag-Cu bimetallic nanoparticles with varying silver contents, demonstrating high antimicrobial activity and potential as a new generation antibacterial agent effective against resistant microorganisms.