Copper Spinel Ferrite Superparamagnetic Nanoparticles as a Novel Radiotherapy Enhancer Effect in Cancer Treatment

In this study, copper spinel ferrite superparamagnetic nanoparticles (CuFe(2)O(4)SPMNPs) were synthesized by a hydrothermal reaction method properly. Here, combination effect of radiotherapy (RT) and CuFe(2)O(4)SPMNPs as radiosensitizer of X-ray radiation, on the MCF-7 breast cancer cells were assessed. Magnetic, crystalline structure, optical and morphological properties of CuFe(2)O(4)SPMNPs were studied by vibration sample magnetometer (VSM), X-ray diffraction (XRD), Fourier transform infrared (FTIR), UV-visible spectrophotometer (UV-vis), atomic force microscopy (AFM) and scanning electron microscopy (SEM). Cytotoxicity and viability of cancer cells exposed to superparamagnetic CuFe(2)O(4)NPs at different concentrations was studied by MTT assay. Cell viability results showed that the CuFe(2)O(4)SPMNPs not only had high increasing in the cell destruction under X-ray radiation (6-MV), but also no significant cytotoxicity at low concentrations was observed. Furthermore, superparamagnetic properties of CuFe(2)O(4)NPs make it easy to localize and displace, by external magnetic field. Therefore, results suggested that CuFe(2)O(4)SPMNPs, are a promising option as an application for treatment of breast cancer cells by RT due to their high cell destruction and low cytotoxicity effects.

Automated summary

The study demonstrated that copper spinel ferrite superparamagnetic nanoparticles can effectively destroy MCF-7 breast cancer cells under X-ray radiation with high cell destruction and low cytotoxicity effects at low concentrations, making them a promising option for breast cancer treatment.