Journal
JOURNAL OF CLINICAL VIROLOGY
Volume 129, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jcv.2020.104543
Keywords
SARS-CoV-2; Influenza; Covid-19; PCR; Infection; FilmArray
Categories
Funding
- Yamanashi Prefecture
- Japan Society for the Promotion of Science (JSPS) KAKENHI EarlyCareer Scientists [JP18K16292, 20H03668]
- YASUDA Medical Foundation
- Uehara Memorial Foundation
- Medical Research Grants from the Takeda Science Foundation
- Grants-in-Aid for Scientific Research [20H03668] Funding Source: KAKEN
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Background: Severe acute respiratory coronavirus 2 (SARS-CoV-2) has spread and caused death worldwide. Preventive measures and infection control are underway, and some areas show signs of convergence. Other viruses in addition to SARS-CoV-2 cause cold-like symptoms and spread in the winter. However, the extent to which SARS-CoV-2, influenza viruses and other causative viruses have prevailed since implementing preventive measures is unclear. Objectives: We aim to investigate the incidence of causative viruses and pathogens in patients. Study design: We collected 191 nasopharyngeal swabs from patients with cold-like symptoms in Japan. All samples were subjected to multiplex PCR with the FilmArray Respiratory Panel and reverse transcription PCR (RT-PCR) to detect SARS-CoV-2. Results: FilmArray Respiratory Panel analysis detected at least one virus in 32 of 191 patients with cold-like symptoms (21 %). Of these, we frequently identified human rhinoviruses/enteroviruses (5.8 %, n=11), human metapneumovirus (3.7 %, n=7), coronavirus 229E (2.1 %, n=4) and coronavirus OC43 (1.6 %, n=3); while no influenza viruses were detected. RT-PCR analysis detected SARS-CoV-2 (4.2 %, n=8) in patients who were not infected with the aforementioned respiratory viruses. Conclusions: Co-infection with SARS-CoV-2 and other viruses was not observed. Causative viruses remain pre-valent after implementing preventive measures. SARS-CoV-2 differs from influenza viruses in its infectivity.
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