Journal
CLINICAL CARDIOLOGY
Volume 40, Issue 5, Pages 287-291Publisher
WILEY
DOI: 10.1002/clc.22657
Keywords
peripheral artery disease; critical limb ischemia; diabetes; mortality; meta-analysis
Categories
Ask authors/readers for more resources
BackgroundThere are accumulating studies showing the association between diabetes and all-cause mortality in peripheral vascular disease. However, the results in these studies are conflicting regarding the impact of diabetes on outcome. HypothesisDiabetes is associated with increased risk of mortality in peripheral artery disease. MethodsUsing MEDLINE and Scopus, we searched for studies published before January 2016. Additionally, studies were identified by manual search of references of original articles or review studies on this topic. Of the 1072 initially identified records, 21 studies with 15,857 patients were included in the final analysis. ResultsDiabetes was associated with a statistically significant increased risk of all-cause mortality (odds ratio: 1.89, 95% confidence interval: 1.51-2.35, P < 0.001), without detected publication bias (Egger bias=0.75, P = 0.631). The stronger effect on outcome was obtained in patients with critical limb ischemia (odds ratio: 2.38, 95% confidence interval: 1.22-4.63, P < 0.001) as the most severe form of peripheral vascular disease. ConclusionsDiabetes is associated with an increased risk of mortality in peripheral vascular disease, and the effect is even more pronounced in patients with critical limb ischemia.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available