Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1626, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.chroma.2020.461366
Keywords
Acyl-transfer; Carbamoylimidazole; Reversed-phase liquid chromatography; Stationary phase; Substituted urea
Funding
- Natural Science Fund for Colleges and Universities in Jiangsu Province [17KJB430 0 05]
- Huai'an Municipal Science and Technology Support Program of China [HAB201701]
- National Natural Science Foundation of China [51802108]
Ask authors/readers for more resources
An alternative method for efficient synthesis of urea-functionalized silanes was proposed on the basis of an N, N'-carbonyldiimidazole-mediated acyl-transfer reaction between various amino-containing building blocks. The employment of different parent aminosilanes and alkylamines afforded an array of urea-containing silanes, which were subsequently immobilized onto silica gel to form corresponding urea-embedded alkyl stationary phases for high-performance liquid chromatography. The different substituents on the silicon core of the derivatized silane were found to significantly influence the final chromatographic behaviors. The comparative chromatographic characterization of thus-prepared silica packings with conventional octadecyl (C18) stationary phases revealed that the urea group was beneficial to suppress silanol activity towards basic probes, as well as to increase the water-compatibility of the alkyl stationary phases. The combination of a polar urea moiety and a non-polar long alkyl chain was favorable for an enhanced steric selectivity towards shape-constrained isomers. The polarizability-sensitive feature of such stationary phases made them good candidates for efficient separation of nitro-containing polar substances. (c) 2020 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available