Journal
JOURNAL OF CELLULAR PHYSIOLOGY
Volume 236, Issue 2, Pages 1105-1115Publisher
WILEY
DOI: 10.1002/jcp.29919
Keywords
autonomic nervous system; exercise; metabolomics; myocardial infarction; ovariectomy
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Funding
- Fundacao de Amparo a Pesquisa do Estado de SAo Paulo (FAPESP) [2013/14788-9]
- CoordenacAo de Aperfeicoamento de Pessoal de Nivel Superior - Brasil (CAPES) [001]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq-BPQ) [309684/2016-1]
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The study evaluated the impact of aerobic training on autonomic, cardiometabolic, ubiquitin-proteasome activity, and inflammatory changes in ovariectomized rats with myocardial infarction. Aerobic training improved physical capacity, increased interleukin-10, and decreased pro-inflammatory cytokines. Metabolomic analysis revealed distinct metabolic profiles among different groups, with aerobic training group showing prevention of certain metabolic responses.
This study aimed to evaluate the impact of aerobic training (AT) on autonomic, cardiometabolic, ubiquitin-proteasome activity, and inflammatory changes evoked by myocardial infarction (MI) in ovariectomized rats. Female Wistar rats were ovariectomized and divided into four groups: sedentary + sham (SS), sedentary + MI (SI), AT + sham surgery (TS), AT + MI (TI). AT was performed on a treadmill for 8 weeks before MI. Infarcted rats previously subjected to AT presented improved physical capacity, increased interleukin-10, and decreased pro-inflammatory cytokines. Metabolomic analysis identified and quantified 62 metabolites, 9 were considered significant by the Vip Score. SS, SI, and TS groups presented distinct metabolic profiles; however, TI could not be distinguished from the SS group. MI dramatically increased levels of dimethylamine, and AT prevented this response. Our findings suggest that AT may be useful in preventing the negative changes in functional, inflammatory, and metabolic parameters related to MI in ovariectomized rats.
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