Journal
JOURNAL OF CELLULAR PHYSIOLOGY
Volume 236, Issue 1, Pages 468-479Publisher
WILEY
DOI: 10.1002/jcp.29874
Keywords
clustering analysis; functional enrichment analysis; gene ontology; Proteus mirabilis; two-component system
Categories
Funding
- Indian Council of Medical Research [IRIS ID: 2019-0810]
Ask authors/readers for more resources
P. mirabilis is a common pathogen in patients with urinary tract infections, showing multidrug resistance. By analyzing the evolutionary relationship and antimicrobial resistance genes of 29 strains of P. mirabilis, researchers can develop new strategies to combat multidrug-resistant strains effectively.
Proteus mirabilisis one among the most frequently identified pathogen in patients with the urinary tract infection. The multidrug resistance exhibited byP. mirabilisrenders the treatment ineffective, and new progressive strategies are needed to overcome the antibiotic resistance (AR). We have analyzed the evolutionary relationship of 29P. mirabilisstrains available in the National Center for Biotechnology Information-Genome database. The antimicrobial resistance genes ofP. mirabilisalong with the enriched pathways and the Gene Ontology terms are analyzed using gene networks to understand the molecular basis of AR. The genesrpoB, tufB, rpsl, fusA, andrpoAcould be exploited as potential drug targets as they are involved in regulating the vital functions within the bacterium. The drug targets reported in the present study will aid researchers in developing new strategies to combat multidrug-resistantP. mirabilis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available