Gene interaction network approach to elucidate the multidrug resistance mechanisms in the pathogenic bacterial strainProteus mirabilis

Proteus mirabilisis one among the most frequently identified pathogen in patients with the urinary tract infection. The multidrug resistance exhibited byP. mirabilisrenders the treatment ineffective, and new progressive strategies are needed to overcome the antibiotic resistance (AR). We have analyzed the evolutionary relationship of 29P. mirabilisstrains available in the National Center for Biotechnology Information-Genome database. The antimicrobial resistance genes ofP. mirabilisalong with the enriched pathways and the Gene Ontology terms are analyzed using gene networks to understand the molecular basis of AR. The genesrpoB, tufB, rpsl, fusA, andrpoAcould be exploited as potential drug targets as they are involved in regulating the vital functions within the bacterium. The drug targets reported in the present study will aid researchers in developing new strategies to combat multidrug-resistantP. mirabilis.

Automated summary

P. mirabilis is a common pathogen in patients with urinary tract infections, showing multidrug resistance. By analyzing the evolutionary relationship and antimicrobial resistance genes of 29 strains of P. mirabilis, researchers can develop new strategies to combat multidrug-resistant strains effectively.