Journal
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
Volume 24, Issue 14, Pages 7789-7801Publisher
WILEY
DOI: 10.1111/jcmm.15410
Keywords
AMPK; epithelial-mesenchymal transition; lung cancer; metabolism
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Funding
- National Natural Science Foundation of China [81672281]
- Natural Science Foundation of Jiangsu Province [B:K20191174, BK20171178]
- Social Development Projects of Key R&D Programs in Jiangsu Province [BE2019643]
- General Program of Jiangsu Commission of Health [H2017083]
- Project of Invigorating Health Care through Science, Technology and Education, Jiangsu Provincial Medical Youth Talent [QNRC2016778]
- Foundation of Jiangsu Province Six Talents Peak [2015-WSN-063]
- Xuzhou Medical Young Talents Project (2015)
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AMP-activated protein kinase (AMPK) serves as a supermetabolic regulator that helps maintain cellular energy homeostasis. However, the role of AMPK in glucose metabolism reprogramming in lung cancer remains unclear. Here, our study shows that low AMPK expression correlates with metastasis and clinicopathologic parameters of non-small-cell lung cancer. Low AMPK significantly enhances the Warburg effect in HBE and A549 cells, which in turn induces the expression of mesenchymal markers and enhances their invasion and migration. At the mechanistic level, low AMPK up-regulates HK2 expression and glycolysis levels through HDAC4 and HDAC5. Collectively, our findings demonstrate that low AMPK-induced metabolism can promote epithelial-mesenchymal transition progression in normal bronchial epithelial cells and lung cancer cells, and increase the risk for tumour metastasis.
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