Journal
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
Volume 76, Issue 3, Pages 255-266Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/FJC.0000000000000869
Keywords
TLR; sex difference; blood pressure; hypertension
Funding
- National Institutes of Health (NIH) [PO1 HL-13604]
- Fundacao de Amparo a Pesquisa do Estado de Mato Grosso (FAPEMAT) [0324552/2018]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [305823/2015-9]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [88881.190484/2018-01]
- Fundacao de Amparo a Pesquisa do Estado de Goias (FAPEG)-CAPES [201710267001159]
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Toll-like receptors (TLRs) play an important role in the innate immune system, and recently, they have been shown to be involved in the regulation of blood pressure. The incidence of hypertension is higher in men, and it increases in postmenopausal women. In fact, premenopausal women are protected from cardiovascular disease compared with age-matched men, and it is well established that this protective effect is lost with menopause. However, the molecular mechanisms underlying this protection in women are unknown. Whether or not it could be related to differential activation of the innate immune system remains to be elucidated. This review focuses on (1) the differences between men and women in TLR activation and (2) whether TLR activation may influence the regulation of blood pressure in a sex-dependent manner.
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