Journal
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
Volume 31, Issue 18, Pages 2318-2330Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09205063.2020.1803182
Keywords
Keratin-dopamine conjugate; stimuli-sensitive drug delivery
Funding
- Jiangsu Higher Education Institutions [19KJA310001]
- PAPD
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Drug-loaded nanoparticles have been widely used in the field of tumor treatment due to their low side effects and reduced frequency of administration. In this study, keratin-dopamine conjugate was first synthesized by amidation reaction and then formed nanoparticles by self-polymerization of dopamine segment. Keratin-dopamine conjugate nanoparticles (KNPs) exhibited pH and glutathione (GSH) dual responsiveness in the simulated tumor environment. These nanoparticles were able to load anti-cancer drug doxorubicin (DOX) through electrostatic interactions and hydrogen bonds. These drug-loaded KNPs (DKNPs) exhibited controlled drug release in a tumor simulation environment. Meanwhile, DKNPs performed a stronger inhibitory effect on tumor cells compared with human normal tissue cells. Based on the above results, keratin-dopamine conjugate based drug carriers had a broad prospect in the field of cancer treatment.
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