Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 23, Issue 9, Pages 884-891Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2020.1791096
Keywords
Aspergillus penicillioides; deep sea-derived fungus; 7 beta,8 beta-epoxy steroid; marine natural products
Funding
- Strategic Priority Research Program of Chinese Academy of Sciences [XDA22050401]
- Aoshan Scientific and Technological Innovation Project of Qingdao National Laboratory for Marine Science and Technology [2016ASKJ14]
- National Natural Science Foundation of China [31700043]
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A new steroid, 7 beta,8 beta-epoxy-(22E,24R)-24-methylcholesta-4,22-diene-3,6-dione (1), was isolated from the deep sea-derived fungus, Aspergillus penicillioides SD-311, along with five known analogues. Compound 1 possessed a rare 7,8-epoxidation moiety, and this is the first report of natural products from this fungus species. The structures were determined by extensive spectroscopic analysis, and the absolute configuration was established by X-ray diffraction experiments.
7 beta,8 beta-epoxy-(22E,24R)-24-methylcholesta-4,22-diene-3,6-dione (1), a new steroid, along with five known analogues (2-6), was isolated from the deep sea-derived fungus,Aspergillus penicillioidesSD-311. Strikingly,1possessed a rare 7,8-epoxidation moiety. Meanwhile, this is the first time to report natural products from this fungus species. The structures were established by extensive spectroscopic analysis. The absolute configuration was determined by X-ray diffraction experiments. Compound1showed antibacterial activity againstVibrio anguillarumwith MIC value of 32.0 mu g/mL, while2displayed inhibitions againstEdwardsiella tardaandMicrococcus luteuswith MIC values both of 16 mu g/mL. [GRAPHICS] .
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