Journal
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
Volume 23, Issue 8, Pages 717-723Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/10286020.2020.1779707
Keywords
Liliaceae; Polygonatum odoratum; anthraquinone analogue; influenza A virus; polygodoquinone A
Funding
- CAMS Innovation Fund for Medical Sciences [2016-I2M-2-002]
- National Infrastructure of Microbial Resources [NIMR-2019-3]
- National Natural Science Foundation of China [81973220]
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Three anthraquinone analogues were isolated from the roots of Polygonatum odoratum, and one of them was identified as a new anthraquinone derivative with unusual structure. These compounds exhibited significant influenza virus inhibitory activity, with IC(50) values better than ribavirin.
Three anthraquinone analogues (1-3) were isolated by phytochemical work on EtOAc-soluble ingredients extracted from the roots ofPolygonatum odoratum. The structures of all isolates were elucidated by NMR, MS and CD experiments, of which1(polygodoquinone A) was identified as a new anthraquinone derivative. Specifically,1represents an unusual structure composed of a naphthoquinone derivative linked to an anthraquinone via a C-C bond.1-3exhibited remarkable influenza A virus inhibitory activity with IC(50)values of 11.4, 11.0, and 2.3 mu M, respectively, which were better than ribavirin as the positive control.
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