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Epidemiology of mobile colistin resistance genes mcr-1 to mcr-9

Journal

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Volume 75, Issue 11, Pages 3087-3095

Publisher

OXFORD UNIV PRESS
DOI: 10.1093/jac/dkaa205

Keywords

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Funding

  1. National Key Research and Development Program of China [2018YFD0500300]
  2. National Natural Science Foundation of China [81861138051]
  3. MRC-NSFC DXC (DETER-XDR-China)-HUB [MR/S013768/1]
  4. China Scholarship Council [CSC: 201806350274]
  5. BBSRC [BB/R012776/1] Funding Source: UKRI
  6. MRC [MR/S013768/1] Funding Source: UKRI

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The identification of the first mobile colistin resistance (MCR) gene, mcr-1, in 2015 triggered a rash of mcr screening reports. Subsequently, nine MCR-family genes and their variants have been described. However, a comprehensive overview concerning the epidemiology of the whole MCR family, which is essential for facilitating rational interventions against mcr dissemination, is Lacking. Here, based on the National Database of Antibiotic Resistant Organisms and published studies, we have summarized the Latest epidemiological characteristics of the mcr genes.

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