Journal
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume 68, Issue 31, Pages 8185-8194Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.0c01931
Keywords
blueberry anthocyanin; hyperlipidemia; insulin resistance; sphingolipids; ceramide metabolism
Funding
- National Natural Science Foundation of China [31972090]
- Liaoning Revitalization Talents Program [XLYC1807127]
- Project of Double Hundred for Major Scientific and Technological Achievement Transformation of Shenyang Science and Technology Bureau [Z19-3-012]
- Scientific Research Foundation of Shenyang Agricultural University [880418074]
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Blueberry anthocyanin-rich extract (BAE) was supplemented to high-fat diet (HFD)-fed mice to investigate sphingolipid metabolism modulating factors involved in the attenuated hyperinsulinemia and hyperlipidemia. A BAE-containing diet effectively controlled food intake and liver weight and significantly attenuated insulin resistance triggered by a HFD. Higher BAE (200 mg/kg of body weight) administration performed more efficiently in the improvement of hepatic steatosis and adipocyte hypertrophy, together with distinct suppressions in serum triacylglycerol and cholesterol in total and species. Serum lipid compositions revealed 200 mg/kg of BAE supplementation remarkably suppressed ceramide accumulation. Consistently, genes encoding enzymes associated with sphingomyelin conversion and ceramide de novo synthesis were modulated toward a healthy direction for restrained sphingolipid accumulation. Further, the inhibited mRNA expressions of protein phosphatase 2A and protein kinase C sigma involved in blocking Akt phosphorylation connected the controlled ceramides with the restored insulin sensitivity.
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