Journal
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
Volume 70, Issue 16, Pages 1189-1202Publisher
TAYLOR & FRANCIS AS
DOI: 10.1080/00914037.2020.1785457
Keywords
Amphotericin B; coaxial electrospraying; core-shell nanoparticles; leishmaniasis; nanoparticles; poly(epsilon-caprolactone)
Categories
Funding
- CNPq
- FAPEMIG
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
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The use of positively charged PCL nanoparticles to encapsulate AMB for the treatment of leishmaniasis is effective, as it can enhance drug encapsulation efficiency and reduce cytotoxicity to cells.
Poly(epsilon-caprolactone) (PCL) electrosprayed nanoparticles (NPs) containing Amphotericin B (AMB) were prepared for the treatment of leishmaniasis. Two variations of PCL nanoparticles with positive surface charges, which can enhance cell uptake and restrict agglomeration, were produced: (1) NPs containing stearylamine and (2) core-shell nanoparticles, with chitosan in the shell and PCL and AMB in the core. The results proved the viability of producing positively charged PCL nanoparticles with AMB, with diameters <350 nm. The encapsulation efficiency of the drug was higher than 75%. The electrosprayed nanoparticles containing AMB were much less cytotoxic to cells than that of pure AMB. [GRAPHICS] .
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