Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 585, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.ijpharm.2020.119506
Keywords
Antibacterial layer-by-layer coating; Soft contact lenses; Controlled release; Hydrostatic pressure sterilization; Chitosan; Alginate; Hyaluronan
Categories
Funding
- COMPETE 2020 [UID/QUI/00100/2019, PTDC/CTM-BIO/3640/2014, PEst-C/EQB/UI0102/2019]
- FEDER [UID/QUI/00100/2019, PTDC/CTM-BIO/3640/2014, PEst-C/EQB/UI0102/2019]
- Fundacao para a Ciencia e Tecnologia (FCT, Portugal) [UID/QUI/00100/2019, PTDC/CTM-BIO/3640/2014, PEst-C/EQB/UI0102/2019, PD/BD/114088/2015]
- MINECO (Spain) [SAF2017-83118-R]
- Agencia Estatal de Investigacion (AEI, Spain)
- Xunta de Galicia (Spain) [AEMAT ED431E 2018/08]
- Fundação para a Ciência e a Tecnologia [PD/BD/114088/2015, PTDC/CTM-BIO/3640/2014] Funding Source: FCT
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A layer-by-layer (LbL) coating was designed using ionic polysaccharides (chitosan, sodium alginate, sodium hyaluronate) and genipin (crosslinker), to sustain the release of diclofenac sodium salt (DCF) from soft contact lens (SCL) materials. The coating was hydrophilic, biocompatible, non-toxic, reduced bacterial growth and had minor effects on the physical properties of the material, such as wettability, ionic permeability, refractive index and transmittance, which remained within the recommended values for SCLs. The coating was applied on a silicone-based hydrogel and on commercial SofLens and Purevision SCLs. The coating attenuated the initial drug burst and extended the therapeutic period for, at least, two weeks. Relevantly, the problems of sterilizing drug loaded SCLs coated with biopolymers, using classic methods that involve high temperature or radiation, were successfully solved through high hydrostatic pressure (HHP) sterilization.
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