Journal
INTERNATIONAL JOURNAL OF NANOMEDICINE
Volume 15, Issue -, Pages 5873-5899Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S255637
Keywords
supramolecular vesicles; amphiphilic pillar[n]arenes; smart; drug delivery
Funding
- Specialized Research Fund for the Doctoral Program of Hebei Agricultural University [ZD201712]
- Undergraduate innovation and entrepreneurship training program [201810086062]
- Natural Science Foundation of Hebei Province [B2019204243]
- Science & Technology Fund of Hebei Agricultural University [LG201811]
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Supramolecular vesicles are the most popular smart nano-drug delivery systems (SDDs) because of their unique cavities, which have high loading carrying capacity and controlled-release action in response to specific stimuli. These vesicles are constructed from amphiphilic molecules via host-guest complexation, typically with targeted stimuli-responsive units, which are particularly important in biotechnology and biomedicine applications. Amphiphilic pillar[n]arenes, which are novel and functional macrocyclic host molecules, have been widely used to construct supramolecular vesicles because of their intrinsic rigid and symmetrical structure, electron-rich cavities and excellent properties. In this review, we first explain the synthesis of three types of amphiphilic pillar[n]arenes: neutral, anionic and cationic pillar[n]arenes. Second, we examine supramolecular vesicles composed of amphiphilic pillar[n] arenes recently used for the construction of SDDs. In addition, we describe the prospects for multifunctional amphiphilic pillar[n]arenes, particularly their potential in novel applications.
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