Journal
CLINICAL AND VACCINE IMMUNOLOGY
Volume 24, Issue 1, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/CVI.00405-16
Keywords
immunization; low and middle-income countries; maternal; rotavirus
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Funding
- National Institute of Allergy and Infectious Diseases [R56AI108515, 5R01AI099601-05]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R56AI108515, R01AI099601] Funding Source: NIH RePORTER
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The role of maternal immunity, received by infants either transplacentally or orally from breast milk, in rotavirus vaccine (RV) performance is evaluated here. Breastfeeding withholding has no effect on vaccine responses, but higher levels of transplacental rotavirus-specific IgG antibody contribute to reduced vaccine seroconversion. The gaps in knowledge on the factors associated with low RV efficacy in low- and middle-income countries (LMIC) remain, and further research is needed to shed more light on these issues.
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