Journal
CLINICAL AND VACCINE IMMUNOLOGY
Volume 23, Issue 9, Pages 795-799Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/CVI.00088-16
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Funding
- HHS \ National Institutes of Health (NIH) [AI91078, AI055429, AI098774]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R43AI091078, R01AI098774, T32AI055429] Funding Source: NIH RePORTER
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PB10 is a murine monoclonal antibody against an immunodominant epitope on ricin toxin's enzymatic subunit. Here, we characterize a fully humanized version of PB10 IgG1 (hPB10) and demonstrate that it has potent in vitro and in vivo toxin-neutralizing activities. We also report the minimum serum concentrations of hPB10 required to protect mice against 10 times the 50% lethal dose of ricin when delivered by injection and inhalation.
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