Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 21, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/ijms21113972
Keywords
peripheral nerve adhesion; anti-adhesive membrane; E8002; L-ascorbic acid; antioxidant
Funding
- Japan Society for the Promotion of Science (JSPS) KAKENHI [JP16K10746]
- General Insurance Association of Japan
- ZENKYOREN (National Mutual Insurance Federation of Agricultural Cooperatives) of Japan
- Mitsui Sumitomo InsuranceWelfare Foundation of Japan
- Descente and Ishimoto Memorial Foundation or the Promotion of Sports Science
- Taiju Life Social Welfare Foundation
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Perineural adhesions leading to neuropathy are one of the most undesirable consequences of peripheral nerve surgery. However, there are currently no widely used compounds with anti-adhesive effects in the field of peripheral nerve surgery. E8002 is a novel, anti-adhesive, multi-layer membrane that contains L-ascorbic acid (AA). Here, we investigated the effect and mechanism of E8002 in a rat sciatic nerve adhesion model. A total of 21 rats were used. Six weeks after surgery, macroscopic adhesion scores were significantly lower in the E8002 group (adhesion procedure followed by nerve wrapping with E8002) compared to the E8002 AA(-) group (adhesion procedure followed by nerve wrapping with the E8002 membrane excluding AA) and adhesion group (adhesion procedure but no treatment). Correspondingly, a microscopic examination revealed prominent scar tissue in the E8002 AA(-) and adhesion groups. Furthermore, an in vitro study using human blood samples showed that AA enhanced tissue-type, plasminogen activator-mediated fibrinolysis. Altogether, these results suggest that E8002 may exert an anti-adhesive action via AA and the regulation of fibrinolysis.
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