Journal
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
Volume 45, Issue 1, Pages 54-61Publisher
WILEY
DOI: 10.1111/ceo.12872
Keywords
Alzheimer disease; amyloid beta; biomarker; ocular; retina
Categories
Funding
- Yulgilbar Alzheimer's Research Program
- Joan Margaret Ponting Charitable Trust
- University of Melbourne, Annemarie Mankiewicz-Zelkin Fellowship
- National Health and Medical Research Council Career Development Fellowship [1090466]
- Victorian Government
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Interest in reliable biomarkers of Alzheimer disease, the leading cause of dementia, has been fuelled by challenges in diagnosing the disease and monitoring disease progression as well as the response to therapy. A range of ocular manifestations of Alzheimer disease, including retinal and lens amyloid-beta accumulation, retinal nerve fiber layer loss, and retinal vascular changes, have been proposed as potential biomarkers of the disease. Herein, we examine the evidence regarding the potential value of these ocular biomarkers of Alzheimer disease.
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