Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 162, Issue -, Pages 1692-1698Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2020.07.282
Keywords
Hydrogel; Carboxymethyl chitosan; Wound dressing; Oxidized hydroxyethyl cellulose
Funding
- National Natural Science Foundation of China [51773161]
- Open Research Fund Program of Hubei-MOST KLOS KLOBME [2019-02]
- Science and Technology Innovation Project of Rizhao City (Foundation) [2019CXZX1108]
- University-industry Cooperation Projects of The Ministry of Education of Guangdong province [2012B091100437]
- innovation fund project of the Ministry of Science and Technology of Small and Medium-sized Enterprises [11C26214202642, 11C26214212743]
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Hydrogel wound dressing is a type of hydrophilic polymer, which has been widely studied and applied in bio medical field. In this study, a simple and non-toxic method was developed to prepare a new type of composite hydrogel, which was formed through the Schiff-base reaction between the aldehyde of Oxidized Hydroxyethyl Cellulose (OHEC) and the amino of Carboxymethyl Chitosan (CMCS). Hence, a series of tests toward this new composite hydrogel which contained its structure and performance was applied. Statistics achieved from those tests showed that this composite hydrogel comprised of some high-quality properties such as suitable gelation time, good swelling ability, suitable water evaporation rate, good blood compatibility and biocompatibility. Considering these properties, this hydrogel has a potential to be explored as wound dressing. (C) 2020 Elsevier B.V. All rights reserved.
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