Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 152, Issue -, Pages 199-206Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2020.02.214
Keywords
Glycosaminoglycans; Hyaluronan; Chemical synthesis; Chemoenzymatic synthesis
Funding
- National Institutes of Health [DK111958, U01CA231074]
- Open Projects Fund of Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology, Shandong University [2019CCG03]
- Natural Science Research Project of Jiangsu Higher Education Institutions [19KJB150013, 19KJB150012]
Ask authors/readers for more resources
Hyaluronic acid (HA) is a major glycosaminoglycan, a family of structurally complex, linear, anionic hetero-co-polysaccharides. HA is important in various anatomical structures including the eyes, joints, heart and myriad intricate tissues, and is currently widely used in the therapeutics and cosmetics areas. The synthesis of HA of well-defined and uniform chain lengths is of major interest for the development of safer and more reliable drugs and to gain a better understanding of its structure-activity relationships. However, HA has received less attention from the synthetic carbohydrate community compared with other members of the glycosaminoglycan family. In this review, we examine the remarkable progress that has been made in the chemical and chemoenzymatic synthesis of HA, providing a broad spectrum of options to access HA of well controlled chain lengths. (C) 2020 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available