Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 156, Issue -, Pages 186-195Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2020.04.028
Keywords
Golden kiwifruit Peel; lipid homeostasis; Fatty acid metabolism; Gut microbiota
Funding
- National Natural Science Foundation of China [C31671823, C31871752, C31901702]
- Science and Technology Research and Development Program of Shaanxi Province [2017NY-102, 2019NY-125]
- China Postdoctoral Science Foundation [2019M653535]
- Fundamental Research Funds for the Central Universities of Shaanxi Normal University in China [GK201803074, GK201903097]
- Development Program for Innovative Research Team of Shaanxi Normal University [GK201801002]
- Sci-Tech Innovation Team of Shaanxi Province [2019TD-035]
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Golden kiwifruit (Actinidia chinensis) peel is a by-product enriched with polyphenols.The effects of fleshes of two Actinidia chinensis fruits (ACF) and fleshes with peels of two Actinidia chinensis fruits (ACFP) on lipid homeostasis. fatty acid metabolism and gut microbiota was investigated in healthy rats. Intervention of ACF and ACFP for 4 weeks significantly reduced total cholesterol, total triglycerides, and increased the high-density lipoprotein levels in rats. ACF and ACFP ameliorated lipid peroxidation in rats, by the lowering hepatic MDA level and enhancing GSH-Px and SOD activities. In addition, ACFP significantly decreased the saturated fatty acids in serum and increased the polyunsaturated fatty adds in hepatic and scrum of rats. Analysis of gut microbiota revealed that ACE and ACFP evidently increased the microbial richness and diversity of gut microbiota. The Firmicutes/Bacteroidetes ratio was significantly reduced from 3.04 in ND group to 1.34 and 2.12 in ACF and ACFP groups, respectively. Moreover, ACF and ACFP significantly increased the abundance of beneficial bacteria (Lactobacillus and Barnesiella) and reduced harmful bacteria (Entemcoccus, Escherichia, and Staphylococcus). Overall, ACFP exerts more potent health-improving effects than ACF. Our study provides a scientific basis for the development of kiwifruit (including pericarp)-based novel natural products with significant health benefits. (C) 2020 Elsevier B.V. All rights reserved.
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