Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 157, Issue -, Pages 106-118Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2020.03.250
Keywords
Polysaccharide; Structure; Leccinum rugosiceps; Immunomodulatoty; Antitumor
Funding
- Guangdong Science and Technology Department [2014A030313242]
- National Natural Science Foundation of China [31972011]
- Guangzhou Science and Technology Program key projects [201907010035]
- Natural Science Foundation of Guangdong Province [2019A1515011670]
- 111 Project [B17018]
- Fundamental Research Funds for the Central Universities [2019MS101]
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A homogeneous water-soluble flaky polysaccharide named LRP-1 (18.82 kDa) was extracted and purified from the rare edible and medicinal fungi Leccinum rugosiceps. The structure characterization of LRP-1 was analyzed by GPC, GC, GC-MS, FT-IR, SEM, 1D/2D NMR, and its antitumor and immunoregulatory activities were determined. The results show that LRP-1 is a new polysaccharide with a backbone which is mainly composed of -> 1-alpha-D-Fucp-3 ->, -> 1-alpha-D-Rhap-3 ->, -> 1-beta-D-Glcp-6 ->, -> 1-beta-D-Glcp-3 -> ,-> 1-alpha-D-Glcp-4 ->,-> 1-beta-D-Galp-6 -> and -> 1-alpha-D-Manp-6 ->. Results of MTT assay show that LRP-1 inhibit the growth of human hepatoma cells HepG-2 and human breast carcinoma MCF-7 cells in vitro. LRP-1 could also induce the secretion of NO and immune factors (IL-6 and TNF-alpha) of RAW264.7. This study suggests that LRP-1 has potential to be used as nu traceutical food with antitumor and immunoregulatory activities. (C) 2020 Elsevier B.V. All rights reserved.
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