Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 155, Issue -, Pages 103-109Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2020.03.187
Keywords
Hyaluronic acid; ZIF-8; Drug-resistant; Pneumonia
Funding
- Life Science Research Core Services of Northwest Agriculture and Forestry University
- Fundamental Research Funds for the Central Universities [2452017026]
- National Natural Science Foundation of China (NSFC) [31870799, 51703181, 31700707]
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Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most common causes of hospital infection. Here, we showed that hyaluronic acid modified organic metal framework material ZIF-8 could be a Trojan horse of vancomycin (Van) for effective treatment of MRSA infections. The Van-loaded nanoparticles were readily up-taken by macrophages via a CD44-mediated process and collapsed in the acidic condition of endosome/lysosome, as a consequence, it could eradicate MRSA with high efficiency in macrophages. This drug delivery system with negligible toxicity could resolve MRSA infections in a well-established mouse pneumonia model. (C) 2020 Elsevier B.V. All rights reserved.
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