Journal
INSECT SCIENCE
Volume 28, Issue 1, Pages 21-34Publisher
WILEY
DOI: 10.1111/1744-7917.12822
Keywords
dsRNA delivery; nanocarrier; pest control; RNAi efficiency; RNA pesticide
Categories
Funding
- Beijing Natural Science Foundation [6204043]
- National Natural Science Foundation of China [31900363]
- Edanz Group China
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Nanoparticle-mediated RNAi offers advantages in delivering dsRNA/small interfering RNA to improve efficiency, promoting the development and practice of RNAi-based pest management strategies.
RNA interference (RNAi) targeting lethal genes in insects has great potential for sustainable crop protection. Compared with traditional double-stranded (ds)RNA delivery systems, nanoparticles such as chitosan, liposomes, and cationic dendrimers offer advantages in delivering dsRNA/small interfering (si)RNA to improve RNAi efficiency, thus promoting the development and practice of RNAi-based pest management strategies. Here, we illustrate the limitations of traditional dsRNA delivery systems, reveal the mechanism of nanoparticle-mediated RNAi, summarize the recent progress and successful applications of nanoparticle-mediated RNAi in pest management, and finally address the prospects of nanoparticle-based RNA pesticides.
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