Journal
CLINICAL AND EXPERIMENTAL DERMATOLOGY
Volume 41, Issue 6, Pages 659-663Publisher
WILEY
DOI: 10.1111/ced.12866
Keywords
-
Categories
Ask authors/readers for more resources
BackgroundStaphylococcus aureus (SA) colonization/infection is important in the pathophysiology of childhood atopic dermatitis (AD), but the role of Staphylococcus epidermidis (SE) is unknown. AimTo evaluate if SE co-infects with SA and is associated with more severe disease. MethodsAssociations between bacteriological culture results of skin swabs (taken from the most severely affected area and at the antecubital fossa) and SCORing Atopic Dermatitis (SCORAD) score, skin hydration, transepidermal water loss (TEWL) and quality of life (QoL) were evaluated. ResultsIn 100 consecutive patients with AD (aged 12.44.8years), SE was present in 28% and 32% of the swabs taken from the most severe area and the flexural area (antecubital fossa), respectively, whereas SA was present in 69% and 55%, respectively. Binomial logistic regression showed that SE was inversely associated with SA growth in the most severely affected skin site [adjusted odds ratio (aOR)=0.42, 95% CI 0.22-0.81; P=0.01], frequency of emollient usage (aOR=0.50, 95% CI 0.29-0.87; P=0.01) and frequency of oral antihistamine usage (aOR=0.81, 95% CI 0.65-0.10, P<0.05), but positively associated with objective SCORAD (aOR=1.04, 95% CI 1.00-1.02; P<0.05). SE in the antecubital fossa was not associated with SA growth, disease severity, QoL or any clinical parameters. ConclusionsSE may not be just a commensal bystander in the skin microbiota. The organism amensalistically displaces SA and is associated with more severe disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available