Journal
INFLUENZA AND OTHER RESPIRATORY VIRUSES
Volume 15, Issue 1, Pages 19-26Publisher
WILEY
DOI: 10.1111/irv.12787
Keywords
China; COVID-19; epidemiology; pre-symptomatic Transmission
Categories
Funding
- Emergency Response Mechanism Operation Program, Chinese Center for Disease Control and Prevention [131031001000015001]
- National Key Research and Development Project, Ministry of Science and Technology of the People's Republic of China [2020YFC0846900]
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The study investigated the earliest COVID-19 cases detected outside Hubei province to make inferences about transmission dynamics and infection severity. The majority of transmissions occur around illness onset in infected individuals, and pre-symptomatic transmission plays a role. Secondary cases in clusters tend to have less severe illness than primary cases.
Background Between mid-January and early February, provinces of mainland China outside the epicentre in Hubei province were on high alert for importations and transmission of COVID-19. Many properties of COVID-19 infection and transmission were still not yet established. Methods We collated and analysed data on 449 of the earliest COVID-19 cases detected outside Hubei province to make inferences about transmission dynamics and severity of infection. We analysed 64 clusters to make inferences on serial interval and potential role of pre-symptomatic transmission. Results We estimated an epidemic doubling time of 5.3 days (95% confidence interval (CI): 4.3, 6.7) and a median incubation period of 4.6 days (95% CI: 4.0, 5.2). We estimated a serial interval distribution with mean 5.7 days (95% CI: 4.7, 6.8) and standard deviation 3.5 days, and effective reproductive number was 1.98 (95% CI: 1.68, 2.35). We estimated that 32/80 (40%) of transmission events were likely to have occurred prior to symptoms onset in primary cases. Secondary cases in clusters had less severe illness on average than cluster primary cases. Conclusions The majority of transmissions are occurring around illness onset in an infected person, and pre-symptomatic transmission does play a role. Detection of milder infections among the secondary cases may be more reflective of true disease severity.
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