Journal
INFLUENZA AND OTHER RESPIRATORY VIRUSES
Volume 15, Issue 1, Pages 27-33Publisher
WILEY
DOI: 10.1111/irv.12782
Keywords
hospitalization; human adenovirus; pneumonia
Categories
Funding
- Natural Science Foundation of Guangdong Province [2018A030313205, 2019A1515012121]
- 13th five-year-major-projects of China's Ministry of Public Health [2017ZX10103011-004]
- Medical Scientific Research Foundation of Guangdong Province [A2020055]
- Key Research and Development Program of Guangdong Province [2019B111103001]
Ask authors/readers for more resources
This study investigated the prevalence and genotype of HAdVs among children hospitalized with pneumonia in Guangzhou, China from January 2013 to June 2019. The results showed that HAdV-B7 and HAdV-B3 were the common types detected during the study period, with the predominant HAdV genotype shifting from HAdV-B3 in 2015-2016 to HAdV-B7 in 2017-2018. The discrepancies in HAdV detection rates in different study periods and changes in predominant types over time emphasize the importance of continued surveillance.
Background HAdV infection can cause a variety of diseases. Although infections with HAdVs often are mild, life-threatening respiratory disease can occur. Pneumonia is one of the more serious types of HAdV-induced respiratory disease in children. In this study, we determined the prevalence and genotype of HAdVs among children hospitalized with pneumonia in Guangzhou, China. Methods Nasopharyngeal swabs (NPSs) were collected from children hospitalized with pneumonia in Guangzhou, China, from January 2013 to June 2019. HAdVs were detected by real-time polymerase chain reaction assay, and hexon, fiber, and penton gene were amplified and used for phylogenetic analysis. Epidemiological data were analyzed using SPSS16.0 software. Results and Conclusions A total of 1778 children hospitalized with pneumonia were enrolled. The overall HAdV detection rate was 3.26%. And the yearly detection rate varied from around 2.5% in 2013-2017 to around 6% in 2018-2019. Children >5 years had the highest HAdV infection rate. 92.86% of HAdV sequences obtained in this study were belonged to species B, and no recombination was observed. HAdV-B7 and HAdV-B3 were the common types detected in the study period, with the predominant HAdV genotype shifted from HAdV-B3 in 2015-2016 to HAdV-B7 in 2017-2018. The discrepancies in HAdV detection rates in different study period and changes of HAdV predominant types over time highlighted the importance of continued surveillance.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available